Where operational alignment drives measurable performance across the network. Learn more about our past success stories.
Study Snapshot:
- Study status: Actively enrolling
- Populace role: Added 5 new research sites to support enrollment acceleration
- Operational challenge: High screen-fail rate across the study
- Primary goal: Increase randomizations without increasing avoidable screen failures
The Challenge:
A Phase 3 psoriasis study was already enrolling but was experiencing high screen-fail rates, creating unnecessary burden on patients, coordinators, and sponsor resources. Populace was brought in to add enrollment capacity through 5 new dermatology sites while improving the quality of patients entering screening.
What Populace Changed:
- Added a protocol-specific prescreen step before formal screening
- Used dermatology practice access, EMR review, and chart matching to identify likely-fit patients
- Built referral pathways into a consistent prescreen workflow
- Held weekly site check-ins to identify screen-fail trends and correct process gaps quickly
Why It Matters:
Adding sites is not enough if those sites reproduce the same screening inefficiencies. Populace helps sponsors scale enrollment by improving both site capacity and patient fit, so more patients move from interest to randomization.
Study Snapshot:
- Study status: Enrolling and ramping across active sites
- Populace role: Multi-site enrollment optimization and patient pathway design
- Illustrative site footprint: 6 research sites supported
- Operational challenge: High interest but inconsistent conversion through memory screening and biomarker steps
- Primary goal: Move the right patients through a complex eligibility pathway faster
The Challenge:
Early Alzheimer’s trials often have no shortage of patient interest, but interest does not always convert into enrollment. Sites must manage cognitive screening, caregiver coordination, biomarker-related steps, p-tau handling, and confirmatory visits. Without a consistent pathway, patients can drop off between steps.
What Populace Changed:
- Built a standardized front-door triage process for every inquiry
- Prioritized likely-fit patients using clinic access and chart review
- Coordinated memory screening, lab steps, and follow-up visits
- Reduced handoff delays between prescreening, screening, and enrollment
- Reviewed site-level funnel metrics weekly: inquiry, prescreen, screen, progression, enrollment
Why It Matters:
In early Alzheimer’s research, enrollment is not just recruitment. It is operational choreography. Populace helps sites create repeatable pathways so complex trials become easier to execute across multiple locations.
Study Snapshot:
- Study status: Actively enrolling
- Populace role: Enrollment acceleration and screening optimization
- Illustrative site footprint: 4 Populace-supported sites within a broader multi-site study
- Operational challenge: Eosinophil eligibility could only be confirmed after screening blood draw
- Primary goal: Build enough patient volume while improving the likelihood that screened patients would qualify
The Challenge:
The study required patients to meet a specific eosinophil threshold, but eligibility could not be confirmed until after a blood draw. This made enrollment expensive and unpredictable. Sites needed a larger funnel, but they also needed a smarter way to decide which patients should move into screening.
What Populace Changed:
- Expanded outreach through respiratory practices and referral networks
- Used clinical signals such as treatment history, exacerbation patterns, and prior labs when available
- Prioritized higher-likelihood candidates before screening blood draws
- Standardized scheduling, lab timing, and follow-up workflows
- Reviewed conversion weekly from inquiry to blood draw, qualified eosinophil result, and randomization
Why It Matters:
When a key eligibility criterion depends on lab confirmation, volume alone will not solve enrollment. Populace helps sites combine broader access with smarter patient prioritization, improving randomization while protecting site time and study quality.
